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Mus musculus
16 Downloadable Samples
Illumina HiSeq 2000
Description
In mice, zygotic activation mainly occurs on a wide variety of genes mainly at the 2-cell stage. Long noncoding RNAs (lncRNAs) are increasingly being recognized as molecules that modulate gene expression. In this study, we performed the directional RNA-seq of MII oocytes and 2-cell embryos to identify the long noncoding RNAs activated during ZGA.
Publication Title
No associated publication
Sample Metadata Fields
No sample metadata fields
View Samples- Mus musculus
- 24 Downloadable Samples
Description
Transgenerational inheritance of an environmentally-induced trait requires that the induced phenotype manifest in generations beyond those that were exposed as germ cells. Here we demonstrate that paternal obesity in mice confers a latent metabolic phenotype not only in F1 sons, but also in F2 grandsons who were never exposed to obesity. F1 and F2 male progeny of obese sires exhibit nearly identical metabolic phenotypes that can be explained in part by stable alterations in hepatic miR-122, a key regulator of fatty-acid metabolism. Both the physiological and molecular alterations induced by paternal obesity are inherited into F2 entirely through the male line, but become attenuated by F3. Our findings demonstrate true transgenerational inheritance of an acquired trait in mammals. The association between the acquired phenotype and levels of several abundant small noncoding RNAs in spermatozoa implicates small RNAs in the mechanism of inheritance.
Publication Title
No associated publication
Sample Metadata Fields
No sample metadata fields
View Samples- Mus musculus
- 3 Downloadable Samples
- Illumina HiSeq 2500
Description
To explore the mechanism of HCC metastasis.
Publication Title
No associated publication
Sample Metadata Fields
Sex, Age, Specimen part, Cell line
View Samples- Caenorhabditis elegans
- 186 Downloadable Samples
- Illumina HiSeq 2000
Description
To investigate the effect of local genetic variation on heritable traits, we developed a new recombinant inbred line (RIL) population derived from four wild isolates. The wild isolates were collected from two closely located sites in France: Orsay and Santeuil. By crossing these four genetically diverse parental isolates a population of 200 RILs was constructed. RNA-seq was used to obtain sequence polymorphisms
Publication Title
No associated publication
Sample Metadata Fields
Sex, Specimen part, Cell line
View Samples- Arabidopsis thaliana
- 35 Downloadable Samples
- Illumina HiSeq 2500
Description
No description.
Publication Title
No associated publication
Sample Metadata Fields
Age, Specimen part
View Samples- Homo sapiens
- 30 Downloadable Samples
- Illumina HiSeq 2500
Description
No description.
Publication Title
No associated publication
Sample Metadata Fields
Sex, Age, Specimen part, Disease
View Samples
SRP045624- Homo sapiens
- 6 Downloadable Samples
- IlluminaHiSeq2000
Description
VHL inactivation is a major component of renal cancer. In this study we re-engineered RCC4 cells to re-express VHL and performed mRNA-sequencing on triplicates to analyse gene and transcript expression changes specific to VHL inactivation.
Publication Title
No associated publication
Sample Metadata Fields
No sample metadata fields
View Samples- Sus scrofa
- 3 Downloadable Samples
- Illumina Genome Analyzer II
Description
We first offered a comprehensive transcriptome from three pig adipose tissues (Hypodermal layer of backfat, greater omentum and mesenteric adipose tissue) by high-throughput RNA-Seq.
Publication Title
No associated publication
Sample Metadata Fields
Sex, Specimen part
View Samples- Homo sapiens
- 496 Downloadable Samples
Affymetrix HT HG-U133+ PM Array Plate (hthgu133pluspm)
Description
Severe asthma is a collection of disease entities with varying pathophysiological characteristics (7) that result in symptoms of cough, wheeze and breathlessness, with frequent exacerbations. To address the problem of phenotypic difference and heterogeneity, the Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes (U-BIOPRED) project was set up as a public-private partnership within the framework of the Innovative Medicines Initiative (IMI), engaging academia, the pharmaceutical industry and patient groups. The goal of this investigation was to identify transcript fingerprints in whole blood that characterize patients with severe asthma and to determine whether subgroups of severe asthmatics can be identified. Furthermore, we were interested in elucidating the biological pathways that showed differences between subgroups.
Publication Title
A Severe Asthma Disease Signature from Gene Expression Profiling of Peripheral Blood from U-BIOPRED Cohorts.
Sample Metadata Fields
Sex, Specimen part, Race
View Samples- Homo sapiens
- 150 Downloadable Samples
- Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)
Description
This SuperSeries is composed of the SubSeries listed below.
Publication Title
Cross-study homogeneity of psoriasis gene expression in skin across a large expression range.
Sample Metadata Fields
Sex, Specimen part, Time
View Samples