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accession-icon GSE48334
The effect of Rapamycin on the transcriptome of old mouse liver
  • organism-icon Mus musculus
  • sample-icon 111 Downloadable Samples
  • Technology Badge IconIllumina MouseRef-8 v2.0 expression beadchip

Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome.

Sample Metadata Fields

Sex, Age, Specimen part, Treatment

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accession-icon GSE48333
The effect of chronic Rapamycin on the transcriptome of old mouse liver
  • organism-icon Mus musculus
  • sample-icon 69 Downloadable Samples
  • Technology Badge IconIllumina MouseRef-8 v2.0 expression beadchip

Description

Analysis of the effect of gene expression in the livers of old mice (25 months of age) fed rapamycin chronically (21 months) from 4 months of age.

Publication Title

Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome.

Sample Metadata Fields

Sex, Age, Specimen part, Treatment

View Samples
accession-icon GSE48331
The effect of short term Rapamycin on the transcriptome of old mouse liver
  • organism-icon Mus musculus
  • sample-icon 42 Downloadable Samples
  • Technology Badge IconIllumina MouseRef-8 v2.0 expression beadchip

Description

Analysis of the effect of gene expression in the livers of old mice (25 months of age) fed rapamycin short term (6 months) Rapamycin from 19 months of age.

Publication Title

Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome.

Sample Metadata Fields

Sex, Age, Specimen part, Treatment

View Samples
accession-icon GSE50568
Expression data from N/Tert-HPV E6 cells in the presence and absence of mitomycin C treatment
  • organism-icon Homo sapiens
  • sample-icon 34 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

HPV E6 from the genus alpha 'high risk' types such as HPV16 recruit the ubiquitin ligase E6AP to ubiquitinate p53 and target it for proteasome-mediated degradation. This results in the functional inactivation of p53 in HPV16-E6 expressing cells.

Publication Title

Genus beta human papillomavirus E6 proteins vary in their effects on the transactivation of p53 target genes.

Sample Metadata Fields

Specimen part, Cell line

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accession-icon GSE23602
Analysis of cohesin-dependent gene regulation in fission yeast
  • organism-icon Schizosaccharomyces pombe
  • sample-icon 12 Downloadable Samples
  • Technology Badge Icon Affymetrix Yeast Genome 2.0 Array (yeast2)

Description

In addition to its well-know function in chromosome segregation, increasing evidence implicates cohesin in the control of gene expression. It has been previously reported that inactivation of the cohesin loader Mis4 in G1-arrested cells leads to the dissociation of cohesin from chromatin. We exploited this experimental situation to ask whether this loss of cohesin would affect gene expression on a genome-wide scale.

Publication Title

Role for cohesin in the formation of a heterochromatic domain at fission yeast subtelomeres.

Sample Metadata Fields

No sample metadata fields

View Samples
accession-icon GSE62064
Radial glia require PDGFD/PDGFRB signaling in human but not mouse neocortex
  • organism-icon Homo sapiens
  • sample-icon 87 Downloadable Samples
  • Technology Badge IconIllumina HumanHT-12 V4.0 expression beadchip

Description

Analysis of gene expression over serial 150um sections of a single gestational week 14.5 human neocortical specimen. The hypothesis tested with this dataset was that a transcriptional signature of radial glia (neural stem cells) could be isolated via unsupervised gene coexpression analysis due to variation in the abundance of this cell type from section to section. This dataset is the first of its kind generated using this method (Gene Coexpression Analysis of Serial Sections, or GCASS).

Publication Title

Radial glia require PDGFD-PDGFRβ signalling in human but not mouse neocortex.

Sample Metadata Fields

Age, Specimen part

View Samples
accession-icon GSE146093
Epigenomic and transcriptomic analysis of Systemic Sclerosis CD4+ T cells
  • organism-icon Homo sapiens
  • sample-icon 64 Downloadable Samples
  • Technology Badge Icon Affymetrix Clariom S Human array (clariomshuman), Infinium MethylationEPIC

Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

Epigenomics and transcriptomics of systemic sclerosis CD4+ T cells reveal long-range dysregulation of key inflammatory pathways mediated by disease-associated susceptibility loci.

Sample Metadata Fields

Sex, Subject

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accession-icon GSE146088
Epigenomic and transcriptomic analysis of Systemic Sclerosis CD4+ T cells [Affymetrix]
  • organism-icon Homo sapiens
  • sample-icon 64 Downloadable Samples
  • Technology Badge Icon Affymetrix Clariom S Human array (clariomshuman)

Description

Epigenomic and transcriptomic analysis of Systemic Sclerosis CD4+ T cells reveals long range dysregulation of key inflammatory pathways mediated by disease-associated susceptibility loci range dysregulation of key inflammatory pathways mediated by disease-associated

Publication Title

Epigenomics and transcriptomics of systemic sclerosis CD4+ T cells reveal long-range dysregulation of key inflammatory pathways mediated by disease-associated susceptibility loci.

Sample Metadata Fields

Sex, Subject

View Samples
accession-icon GSE37859
Compare gene expression profiles of mouse iNSC, WT-NSC, and MEF
  • organism-icon Mus musculus
  • sample-icon 12 Downloadable Samples
  • Technology Badge Icon Affymetrix Mouse Gene 1.0 ST Array (mogene10st)

Description

The iNSC cells are two clones generated from the same MEF line. Therefore, we conducted one analysis that compared the two clonal lines and a separate analysis that compared iNSC vs. NSC, iNSC vs. MEF, and NSC vs. MEF. Both were single factor ANOVAs, the first compared two

Publication Title

Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor.

Sample Metadata Fields

Specimen part

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accession-icon GSE33728
Melanoma cell culture phenotypes
  • organism-icon Homo sapiens
  • sample-icon 15 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

Systematic classification of melanoma cells by phenotype-specific gene expression mapping.

Sample Metadata Fields

Cell line

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refine.bio is a repository of uniformly processed and normalized, ready-to-use transcriptome data from publicly available sources. refine.bio is a project of the Childhood Cancer Data Lab (CCDL)

fund-icon Fund the CCDL

Developed by the Childhood Cancer Data Lab

Powered by Alex's Lemonade Stand Foundation

Cite refine.bio

Casey S. Greene, Dongbo Hu, Richard W. W. Jones, Stephanie Liu, David S. Mejia, Rob Patro, Stephen R. Piccolo, Ariel Rodriguez Romero, Hirak Sarkar, Candace L. Savonen, Jaclyn N. Taroni, William E. Vauclain, Deepashree Venkatesh Prasad, Kurt G. Wheeler. refine.bio: a resource of uniformly processed publicly available gene expression datasets.
URL: https://www.refine.bio

Note that the contributor list is in alphabetical order as we prepare a manuscript for submission.

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