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GSE11370Two distinct mechanisms generate endogenous siRNAs from bidirectional transcription in Drosophila melanogaster.
Drosophila melanogaster
2 Downloadable Samples
Affymetrix Drosophila Genome 2.0 Array (drosophila2)Submitter Supplied Information
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Cis-natural antisense transcripts (cis-NATs) have been speculated to be substrates for endogenous RNA interference (RNAi), but little experimental evidence for such a pathway in animals has been reported. Analysis of massive Drosophila melanogaster small RNA data sets now reveals that endogenous small interfering RNAs (siRNAs) are produced via bidirectional transcription. >100 cis-NATs with overlapping 3' exons generate 21-nt, Dicer-2 (Dcr-2)dependent, 3'-end modified siRNAs.
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